I-77 N

I-77 N to I-85 S; US 321 N to Blowing Rock. From South Charlotte: 485 W to I-85; US 321 to Blowing Rock.

I-40 W

I-40 W to Winston-Salem; US 421 N to Parkway-South; Exit US 221S/321S  to Blowing Rock.

I-95 N

I-95 N to I-26 W; I-26 W to Columbia, SC; I-77 N to 485 W in Charlotte; I-85 S to Gastonia; US 321 N to Blowing Rock.

I-75N

I-75 N to Atlanta ; I-85 N to I-26 W (Spartanburg, SC); I-26 W to Hwy. 74 E; Hwy. 74 E to Hwy. 221 N; Hwy. 221 N to Blowing Rock.

I-85 S

I-85 S to Durham, NC; I-40 W to Winston-Salem ; US Hwy. 421 N to Parkway-South; Exit US 221S/321S to Blowing Rock.

I-85 N

I-85 N to I-26 W (Spartanburg, SC); I-26 W to Hwy. 74 E; Hwy. 74 E to Hwy. 221 N; Hwy. 221 N to Blowing Rock. Note: Hwy. 221 is a scenic route.

I-40 E

I-40 E through Knoxville to intersection to I-81 N; I-81 N to intersection to I-26 S; I-26 S to Johnson City; Hwy. 321 S to Blowing Rock.

I-75 S

I-75 S to Knoxville; I-81 N to intersection to I-26 S; I-26 S to Johnson City; Hwy. 321 S to Blowing Rock.

I-77 S

I-77 S to Hwy. 421 N; Hwy. 421 N to Parkway-South; Exit US 221S/321S to Blowing Rock.

I-81 S

I-81 S to Abingdon, VA; US Hwy. 58 E to TN 91 S; 91 S to Mountain City ; Hwy. 421 S to Boone; NC-105 EXT/US-221; Blowing Rock Rd./US 321/US 221 to Blowing Rock.